: Malaria Red Cell Cytoadherence Response
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چکیده
132-m (2) and tryptophan in Rab 12 kD (1). The possibility that the assignment of tryptophan results from a typographical error in figure 2 of Brinckerhoff et al. (1) is suggested by the misquoted assignment in that figure of tryptophan, instead of tyrosine, at the same position of human P2-m, the only sequence to which Rab 12 kD is compared. PETER PARHAM Department of Cell Biology, Shernan Fairchild Building, Stanford University School ofMedicine, Stanford, CA 94305
منابع مشابه
Continued cytoadherence of Plasmodium falciparum infected red blood cells after antimalarial treatment
Development of severe disease in Plasmodium falciparum malaria infection is thought to be, at least in part, due to the sequestration of trophozoite-stage infected red blood cells in the microvasculature. The process of cytoadherence is mediated by binding of the parasite protein PfEMP-1 on the surface of infected red blood cells to endothelial cell receptors. Although antimalarial treatments r...
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Cerebral malaria is thought to involve specific attachment of Plasmodium falciparum-infected knobby red cells to venular endothelium. The nature of surface ligands on host endothelial cells that may mediate cytoadherence is poorly understood. We have investigated the effects of soluble thrombospondin, rabbit antiserum raised against thrombospondin, and human immune serum on cytoadherence of par...
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Cerebral malaria is thought to involve specific attachment of Plasmodium falciparum-infected knobby red cells to venular endothelium. The nature of surface ligands on host endothelial cells that may mediate cytoadherence is poorly understood. We have investigated the effects of soluble thrombospondin. rabbit antiserum raised against thrombospondin. and human immune serum on cytoadherence of par...
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In severe falciparum malaria cytoadherence of parasitised red blood cells (PRBCs) to vascular endothelium (causing sequestration) and to uninfected red cells (causing rosette formation) contribute to microcirculatory flow obstruction in vital organs. Heparin can reverse the underlying ligand-receptor interactions, but may increase the bleeding risks. As a heparin-derived polysaccharide, sevupar...
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تاریخ انتشار 2005